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Psychedelic Definition & Meaning They suggest that some of the cortical actions of 5-HT may be constantly exerted, with more or less efficacy at the various 5-HT receptors, thus providing widespread global and/or sustained influence in the neocortex. Early receptor mapping studies in rat brain using autoradiography with tritiated antagonist ligands identified brain areas with high 5-HT2 receptor density (Pazos et al., 1985). Highest binding was seen in the claustrum, but with high expression also in all laminae of the neocortex. The highest receptor density within the cortex was localized to a continuous band that included lamina IV and extended into lamina III, depending on the area studied. In humans, PET with N1--methyl)-2-bromo-LSD revealed highest binding in the frontal and temporal cortices, lower expression in parietal cortex and motor regions, with intermediate levels in basal ganglia, and only low levels in thalamus (Wong et al., 1987). To investigate how long-term LSD a